2023 Vol.4 Mar.No1

• Title: Effects of Glycyrrhiza Xiexin Decoction on TLRs/NF-kB signal transduction pathway of intestinal flora disorder in the elderly
• Name: Nanba Keiichi1,heaven and earth ten to chi to2
• Company: 1.Tokyo Senkaku University,katsushika 125-0062,Japan; 2.Bangsong University,Hamamatsu 434-0027,Japan
• Abstract:

  To study the effects of Glycyrrhiza Xiexin Decoction on TLRs/NF-kB signal transduction pathway of intestinal flora disorder in the elderly. Methods 80 patients with ulcerative colitis were randomly divided into control group and experimental group. They were treated with western medicine mesalazine capsules and glycyrrhizin decoction in turn. 40 healthy subjects were selected as the healthy group without any drug treatment. The contents of intestinal flora, intestinal mucosal TLRs and NF-kB p65 expression were measured before the experiment and 3 months after treatment. Results After the experiment, the contents of bifidobacterium and lactobacillus in the intestinal flora of the subjects in the control group and the experimental group were increased, which effectively inhibited the growth of pathogenic bacteria such as Escherichia coli (P<0.05). The expressions of TLRs and NF-kB p65 in intestinal mucosa were decreased (P<0.05). The therapeutic effects of glycyrrhizin decoction and mesalazine were basically the same. Conclusion Glycyrrhiza Xiexin Decoction can regulate the intestinal flora disorder in the elderly, facilitate the expression of TLRs/NF-kB, form an effective signal transduction pathway of TLRs/NF-kB, and correctly transmit body information.

  
  

• Keyword: Glycyrrhiza Xiexin Decoction; The elderly; Intestinal flora disorder; TLRs; NF-kB; Signal transduction pathway
• DOI: 10.12250/jpcarme2023040135
• Citation form: Nanba Keiichi1,heaven and earth ten to chi to2,Effects of Glycyrrhiza Xiexin Decoction on TLRs/NF-kB signal transduction pathway of intestinal flora disorder in the elderly,2023,Vol.4,44-50.

[1] Wang Yan, Li Junxia, Wang Huahong, et al. Relationship of intestinal flora imbalance and immunoglobulin in patients with ulcerative colitis[J]. The Journal of Practical Medicine, 2016, 32(10):1631-1634.

[2] Wang Lin, Zhou Feng, Yan Changsheng, et al. Research progress of gut microbiota dysbiosis after cholecystectomy[J]. Chinese Journal of Digestive Surgery, 2018, 17(3):321-324.

[3] Wang Guoqing, Wei Wenhong, Yang Jie. Effects of Gancao Xiexin Decoction on Serum Levels of IL-17 and IL-23 in Patients with Ulcerative Colitis[J]. Journal of Nanjing University of Traditional Chinese Medicine, 2016, 32(1):25-28.

[4] LuJun qi, wang shan, Jia yoon, et al. A machine learning model using gut microbiome data for predicting changes of trimethylamine-N-oxide in healthy volunteers after choline consumption[J]. Journal of Southern Medical University, 2017, 37(3):290-295.

[5] Liu Donglian, Liao Mengling, Zhou Huan. Research Progress on the Correlation Analysis Between Diabetes and Gut Microbiota Using High Throughput Sequencing[J]. Biotechnology Bulletin, 2016, 32(9):59-64.

[6] Wu Sen, Wu Jiayun, Dai Chaohui, et al. Analysis of TAP1 gene expression in pig intestinal epithelial cells infected by E. coli with IPEC-J2[J]. Animal Husbandry & Veterinary Medicine, 2017, 49(8):53-56.

[7] Wang Jianrong, Wang Yaohui, Gao Lili, et al. Changes and significance of CPS1 and S100P protein expression in intestinal mucosal tissues of ulcerative colitis[J]. Shandong Medical Journal, 2017, 57(10):47-49.

[8] Wang Long, Hu Cui, Wang Jing, et al. The clinical analysis of the levels of urinary sCD14 in ulcerative colitis[J]. Acta Universitatis Medicinalis Anhui, 2017, 52(8):1258-1260.

[9]Han Wenbei, Liu Yinglu, Wan Yigang, et al. Pathological mechanism, treatment strategy and intervention of Chinese medicine in intestinal flora disorder of chronic kidney disease[J]. China Journal of Chinese Materia Medica, 2017, 42(13):2425-2432.

[10] Liu Ruixue, Li Yongchao, Zhang Bo. Research progress on gut microbiota homeostasis and human health[J]. Science and Technology of Food Industry, 2016, 37(6):383-387.

[11] Wang Youduo, Chen Hua. Clinical Observation of Mesalazine Combined with Bifidobacterium Tetravaccine(Live)in the Treatment of Ulcerative Colitis[J]. China Pharmacy, 2016, 27(3):326-328.

[12] Wei Yongfeng. Expression, antibody production and species specificity of SpaA pilin subunit from Lactobacillus rhamnosus[J]. Microbiology China, 2016, 43(6):1288-1294.

[13] Zhou Xia, Ling Bin, Sun Jie, et al. Research progress on the relationship between HMGB1-RAGE/TLRs-NF-κB signaling pathway and sepsis[J]. Shandong Medical Journal, 2016, 56(37):101-103.

[14] Liu Dongxiao, Cheng Long, Wang Xiaoping, et al.Effects on TLRs signaling pathway and proinflammatory factor expression in cell line A549[J]. Journal of Agricultural Biotechnology, 2016, 24(2):252-260.

[15] Wu Zhenhui, Meng Xian, Hu Jiawei, et al. Research progress on the correlation between TLR4-MyD88-NF-κB signalling pathways and the hepatic inflammation-fibrosis-cancer axis[J]. Journal of International Pharmaceutical Research, 2017, 44(5):396-401.