2021 Vol.2 Jun. No.2

• Title: Study on the relationship between apolipoprotein E gene polymorphism and cardiovascular and cerebrovascular diseases in the elde
• Name: Masako Yamako1,Nanba Keiichi2
• Company: (1.Bangsong University,Hamamatsu 434-0027,Japan； 2.Tokyo Senkaku University,katsushika 125-0062,Japan）
• Abstract:

  Objective: To investigate the relationship between apolipoprotein E gene polymorphism and cardiovascular and cerebrovascular diseases in the elderly. Methods: A case-control study was conducted on the basis of a college, and elderly patients over 60 years of age were selected as the subjects for the study. With 200 elderly patients with atherosclerosis as the experimental group and 200 elderly patients with normal cardiovascular and cerebrovascular functions as the control group, the distribution of ApoE gene in this group was determined by gene chip method. Results: ApoE subtype E3 was the most common in patients, with a proportion of 67.1%. Its distribution in elderly cardiovascular and cerebrovascular diseases was basically consistent with that of the population; However, in the population with neurodegeneration, the carrying rate of E4 subtype was higher than that of E2 subtype (P<0.01); In patients of atherosclerosis group and control group ε 2 and ε The levels of triacylglycerol in the 4 alleles were (1.76 ± 2.19) mmol/L, (1.96 ± 1.32) mmol/L and (1.42 ± 1.52) mmol/L, (1.79 ± 1.28) mmol/L, respectively, with significant differences (P<0.05). Triacylglycerol (OR=4.383,45% CI: 2.210 ～ 8.795), high-density lipoprotein cholesterol (OR=0.479,35% CI: 0.315 ～ 0.763), low-density lipoprotein cholesterol (OR=2.371,45% CI: 1.018 ～ 5.253) and ApoE alleles (OR=0.329,93% CI: 0.215 ～ 0.521) were all risk factors of arteriovenous atherosclerosis in the elderly, with significant differences (P<0.01). Conclusion: ApoE polymorphism is related to the level of blood lipid metabolism in elderly patients ε The risk of cardiovascular and cerebrovascular disease increased in alleles.

  
  

• Keyword: Apolipoprotein E gene; Gene polymorphism; Cardiovascular and cerebrovascular diseases in the elderly; Correlation study
• DOI: 10.12250/jpcarme2021010291
• Citation form: Masako Yamako1,Nanba Keiichi2.Study on the relationship between apolipoprotein E gene polymorphism and cardiovascular and cerebrovascular diseases in the elderly.2020, vol. 3, 44-50.

[1] Nascimento J , Pereira L C , JMC Rêgo, et al. Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis[J]. World journal of gastroenterology, 2021, 27(11):1064-1075.
[2] Li Wen. Increased risk of cardiovascular disease in elderly population with carotid plaque and low ankle brachial index[J]. China Medical Abstracts(Internal Medicine), 2021, 38(03):163.
[3]Zhu Jielin, Cui Lijun, Li Lu, et al. Association of Apo E gene polymorphism and laboratory related index in patients with Alzheimer's disease and abnormal mental behavior[J]. Zhejiang Medical Journal, 2020, 42(16):1712-1715.
[4]Gao Yinting, Kong Lulu, Li Wei.Relationship between ApoE Gene Polymorphism and Cerebrovascular Complications in Patients with Type 2 Diabetes Mellitus[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2020, 28(12):46-51.
[5]Liu Limei, Qiu Xu, Chen Ping, et al. Relationship between HCMV infection,apolipoprotein E gene polymorphism and essential hypertension and cardiovascular diseases[J]. Chinese Journal of Nosocomiology, 2021, 31(12):1886-1890.
[6]He Wei, Li Ting, Liang Kun, et al. Distribution of apolipoprotein E and SLCO1B1 gene polymorphisms in elderly patients with cardiovascular and cerebrovascular disease in Bayannur region[J]. Chinese Journal of Clinical Pathologist, 2020, 12(3):176-179.