2021 Vol.2 Jun. No.2

• Title: Correlation between gene polymorphism and hyperlipidemia in risk factors of cardio cerebral diseases
• Name: Egawa Hisao1,Mizushima Yuu2
• Company: (1.Beppu University,Biefu 125-0062,Japan; 2.Tokushima Bunri University,Tokushima 770-0835,Japan)
• Abstract:

  In order to improve the correlation of important risk factors in cardio cerebral diseases, the relationship between gene polymorphism in cardio cerebral disease risk factors and hyperlipidemia was studied. Genotypes of hyperlipidemia patients and healthy people were detected by full sequence gene sequencing, and the genotype constituent ratio, i.e. distribution characteristics, were analyzed to explore the differences, so as to analyze the correlation between gene polymorphism and dyslipidemia. In addition, the syndrome of Qi stagnation and blood stasis was significantly higher than that of spleen and kidney yang deficiency, and the syndrome of phlegm stagnation in E2/2+E2/3 was significantly lower than that of spleen and kidney yang deficiency, the syndrome of Qi stagnation and blood stasis, and the syndrome of liver and kidney yin deficiency ε 4. The allele frequency was significantly higher than that of spleen kidney yang deficiency syndrome. It was concluded that ApoE genotype polymorphism had a certain correlation with TCM syndrome characteristics of hyperlipidemia.

  
  

• Keyword: Cardio cerebral diseases; Hyperlipidemia; Gene polymorphism; Distribution characteristics; Sequencing of whole sequence gene;
• DOI: 10.12250/jpcarme2021010292
• Citation form: Egawa Hisao1,Mizushima Yuu2.Correlation between gene polymorphism and hyperlipidemia in risk factors of cardio cerebral diseases.Correlation between gene polymorphism and hyperlipidemia in risk factors of cardio cerebral diseases.2021,Vol.2,37-43.

[1]YU Bo,SHEN Yufei, LU Xudong, et al. Risk factors of pulmonary infection in patients with acute cerebral infarction and correlation analysis with IL-6 gene - 572C/G gene polymorphism[J]. Chinese Journal of Nosocomiology,2020,30(7):999-1002.

[2]WANG Juan, YANG Liu, QUAN Qiankun, et al. Study on the relationship between apolipoprotein E gene polymorphism, lipid metabolism and cardiovascular and cerebrovascular diseases in the elderly[J]. Chinese Journal of Nosocomiology,2020,39(8):883-886.

[3]WANG Yanan, WANG Mengkun.Influence of regular blood donation without compensation on high risk factors of cardiovascular and cerebrovascular diseases[J]. Journal of Apoplexy and Nervous Diseases,2021,38(12):1103-1105.

[4]WEI Xinhui, HU Xiaoyan. Correlation between calpain-10 gene polymorphism and susceptibility to coronary atherosclerotic heart disease in Han patients with type 2 diabetes in Shaanxi Province[J]. Chinese Journal of Diabetes,2020,28(3):193-196.

[5]MA Yihan, LI Xingyu, LIU Qian, et al. Study on the influence of the times of reaching the standard of blood pressure on the incidence of cardiovascular and cerebrovascular diseases in patients with hypertension[J]. Chinese General Practice,2020,23(28):3608-3614.

[6]CHEN Jin, WU Xiaoguang, YU Yunfu, et al. Association of RAGE gene polymorphism with MHR ratio and heart rate variability in patients with coronary atherosclerotic heart disease [J]. Chinese Journal of Medical Genetic,2021,38(7):681-685.