2021 Vol.2 Jun. No.2

• Title: The influence of statin metabolism related gene detection on the treatment of cardiovascular and cerebrovascular diseases in the
• Name: Yasujirô Ozu,Mizuno Tadashi
• Company: (Nagoya Shaping University,Nagoya 481-0006,Japan)
• Abstract:

  Purpose: Collect and read relevant literature at home and abroad in recent years, summarize and summarize, analyze the value of statin metabolism related genes in the treatment of cardiovascular and cerebrovascular diseases in the elderly, and provide theoretical basis for individualized treatment. There is an inevitable relationship between statin resistance and cardiovascular and cerebrovascular events. Gene polymorphism can significantly affect platelet activity, statin resistance and adverse drug reactions, Gene mutation and gene interaction can make a significant difference in the proportion of statin resistance and the incidence of ischemic cardio cerebral vascular events. Rational adjustment of the drug administration scheme according to the detection results of genes related to drug metabolism can reduce the incidence of statin resistance, ischemic cardio cerebral vascular events and statin side effects. Method: 300 CHD patients admitted to a hospital from January to December 2021 were selected as research objects. All patients were treated with atorvastatin, and total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were detected before and after treatment. At the same time, the genes related to statin metabolism were detected, and the blood lipid levels of CHD patients with different genotypes were observed before and after statin treatment. Result: The genotyping and gene frequency distribution of patients were consistent, with (2677G>T) G allele frequency>T allele, (3435C>T) C allele frequency>T allele; The levels of TC, TG and LDL-C after treatment were significantly lower than those before treatment, and the levels of HDL-C were significantly higher than those before treatment (P<0.05); The levels of TC, TG, LDL-C were significantly lower and HDL-C were significantly higher in all genotype patients after statin treatment (P<0.05). Conclusion: The blood lipid level of patients with cardiovascular and cerebrovascular diseases is abnormal, and there are significant individual differences in gene polymorphism of patients with the same disease. The detection of drug genomics in patients with cardiovascular and cerebrovascular diseases plays an important role in guiding the clinical treatment of statins to reduce blood lipid.

  
  

• Keyword: Statins; Gene detection; Cardio cerebral vessels in the elderly; Disease treatment
• DOI: 10.12250/jpcarme2021010295
• Citation form: Yasujirô Ozu,Mizuno Tadashi.The influence of statin metabolism related gene detection on the treatment of cardiovascular and cerebrovascular diseases in the elderly.2020, vol. 3, 16-20.

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