2020 Vol.1 Dec.No4

• Title: Changes of serum AFP and CEA levels in elderly patients with hepatitis B-related primary liver cancer
• Name: Matsuhiro hiramoto1,Extrauterine bone2
• Company: (1.Ai engineering university,katsushika 125-0062,Japan; 2.West Kyushu University,Fukuoka 810-0042,Japan)
• Abstract:

  Objective In order to diagnose and help the elderly with hepatitis B-related primary liver cancer as early as possible and improve the quality of life of the elderly with liver cancer, the changes of serum AFP and CEA levels in the elderly with hepatitis B-related primary liver cancer were studied. Method 92 cases of hepatitis B-related primary liver cancer, 83 cases of hepatitis B-related cirrhosis and 70 cases of health examination were defined as liver cancer group, liver cirrhosis group and control group. The serum of the three groups were collected and the levels of AFP and CEA in the serum were detected by the automatic biochemical analyzer. Result The results showed that the levels of serum AFP and CEA were significantly higher in liver cancer group than in liver cirrhosis group; the higher the clinical stage, the lower the degree of differentiation, the smaller the tumor and the fewer the number, the higher the level of serum AFP; the sensitivity, accuracy and specificity of combined diagnosis of serum AFP and CEA were 89.25%, 84.44% and 81.98%, respectively, which were higher than single diagnosis results; serum CEA water The higher the level, the higher the survival rate and the lower the recurrence rate. Conclusion It is suggested that the detection of serum AFP and CEA levels is of great value in the diagnosis of hepatitis B-related primary liver cancer in the elderly.

  
  

• Keyword: Hepatitis B in the elderly; Primary liver cancer; Serum; Alpha fetoprotein; Carcinoembryonic antigen;
• DOI: 10.12250/jpcarme2020010435
• Citation form: Matsuhiro hiramoto1,Extrauterine bone2.Changes of serum AFP and CEA levels in elderly patients with hepatitis B-related primary liver cancer.2020, vol. 3,32-37.

[1] Wang Zheng Diagnostic value of combined detection of serum tumor markers in primary liver cancer [J] Chinese Journal of Cancer Prevention and Treatment, 2018, 25 (S1): 90+92

[2] Yu Lin, Zhang Kaijiong, Chai Li, etc Expression of miR-202 in cancer tissues and serum of patients with primary liver cancer and its significance [J] Shandong Pharmaceutical, 2017, 57 (7): 1-4

[3] Zhang Yang, Wu Huili Comparison of effects of different schemes on serum CEA, AFP, CA19-9, TK1 levels and life cycle in elderly patients with advanced colon cancer [J] Chinese Journal of Hospital Pharmacy, 2019, 39 (3): 269-273

[4] Gao Bin, Xiong Yinghui, Huang Zebing, etc Changes of serum exosomal mir-1290 level in patients with hepatitis B related hepatocellular carcinoma and its diagnostic value [J] Chinese Journal of General Surgery, 2019, 28 (1): 31-38

[5] Jiao Yang Clinical characteristics of patients with primary liver cancer with positive and negative hepatitis B virus [J] Chinese Journal of Hepatobiliary Surgery, 2017, 23 (4): 217-221

[6]Bi C, Huang D, Jiang J, et al. Changes of serum sPD-1 levels in HBeAg-positive chronic hepatitis B patients with entecavir treatment and correlation with curative effect[J].  Turkish Journal of Medical Sciences, 2018, 48(2):286-292.

[7] Ding Peng, Li Jiansheng, Ma Jinliang Effect of laparoscopic radiofrequency ablation on postoperative complications and quality of life of patients with primary liver cancer [J] Chinese Journal of Endemic Disease Control, 2017, 32 (11): 1296-1296

[8] Li Chengde, Quan Yi, Cai Jianmei, et al Expression and clinical significance of serum B7-H3 and IL-21 in patients with HBV related primary liver cancer [J] Chinese Journal of Immunology, 2018, 34 (4): 569-575

[9]Ricco G, Cosma C, Bedogni G, et al. Clinical significance of time related fluctuations of AFP and PIVKA-II serum levels in patients with cirrhosis undergoing surveillance for hepatocellular carcinoma[J].  Digestive & Liver Disease, 2018, 50(1):14-15.

[10] Xiao Chaohui, Liu Rong Clinical research progress on molecular markers of postoperative recurrence of liver cancer [J] Chinese Journal of Hepatobiliary Surgery, 2017, 23 (4): 277-281