2020 Vol.1 Jun.  No.2

• Title: Effect of Gancao Xiexin Decoction on TLRs/NF kB Signal Transduction Pathway in Aged Patients with Heart Rate Disorder
• Name: Tsukada Masaaki, Shinjing Liangping
• Company: (Jibei International University,High beam716-0009,Japan)
• Abstract:

  Objective To study the effect of Gancao Xiexin Decoction on TLRs/NF kB signal transduction pathway in elderly patients with heart rate disorder. Methods 80 patients with heart rate disorder were randomly divided into control group and experimental group. They were treated with western medicine and traditional Chinese medicine licorice xiexin decoction in turn; 40 healthy people were selected as the healthy group without any medication. Before the experiment and 3 months after the treatment, the conditions of the subjects were measured respectively. Results After the experiment, the heart rate imbalance of the subjects in the control group and the experimental group was improved (P<0.05); The expression of TLRs and NF kB p65 in intestinal mucosa decreased (P<0.05), and the therapeutic effect of licorice xiexin decoction was basically the same as that of mesalazine. Conclusion Gancao Xiexin Decoction can regulate the heart rate imbalance in the elderly, facilitate the expression of TLRs/NF kB, form effective TLRs/NF kB signal transduction pathway, and correctly transmit body information.

  
  

• Keyword: Licorice Xiexin Decoction; aged; Heart rate disorder; TLRs； NF-kB； signal transduction pathway
• DOI: 10.12250/jpcarme2020010283
• Citation form: Tsukada Masaaki, Shinjing Liangping.Effect of Gancao Xiexin Decoction on TLRs/NF kB Signal Transduction Pathway in Aged Patients with Heart Rate Disorder.2020,Vol.1,44-50.

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