2020 Vol.1 Jun.  No.2

• Title: Effects of exercise qigong on the expression of lipids and lipid-metabolism-related genes in elderly patients with atheroscleros
• Name: Tokugawa Yoshinobu1, Shangshan Qianxin 1, Fumi Hirano 2
• Company: (1.Bangsong University,Hamamatsu 434-0027,Japan; 2.Pure Heart University, Tokyo,The Eighth Prince 192-0043,Japan)
• Abstract:

  Objective In view of the side effects of medication and diet control, and the heavy economic burden, it is proposed to improve the blood lipid and lipid metabolism related gene expression in elderly patients with arteriosclerosis by Fitness Qigong exercise. Methods The 75 elderly patients with atherosclerosis were divided into control group, drug group and fitness qigong group. The three groups were tested for lipoprotein metabolism, lipid level, arterial plaque stability, apolipoprotein E gene defect, lipid metabolism related genes LDLR, LCAT and CD36. Result The results showed that the ApoA1 and ApoA1/B of lipoprotein in the fitness qigong group were significantly higher than those before the experiment, the control group and the medication group, and the ApoB was significantly lower than those before the experiment, the control group and the medication group. The ratio of plaque lactone core, plaque lactone components and collagen components in the fitness qigong group and the medication group was lower than that in the control group (P<0.01). The HDLC concentration of blood lipid in the fitness qigong group was significantly higher than that in the control group and the medication group. Compared with the comparison table, TC-HDL /HDL, TG and TC decreased significantly. In terms of genes related to lipid metabolism, compared with the control group, the levels of LDLR and LCAT mRNA in the fitness qigong group and the medication group were significantly increased, and the expression of CD36 gene in the aorta was significantly decreased (P<0.05). Conclusion It indicates that the exercise of fitness qigong has obvious effect on improving the expression of lipids and lipid-metabolization-related genes in elderly patients with atherosclerosis.

  
  

• Keyword: Health qigong; Old age; Atherosclerosis; Blood lipid; Lipid metabolism; Gene expression
• DOI: 10.12250/jpcarme2020010286
• Citation form: Tokugawa Yoshinobu, Shangshan Qianxin, Fumi Hirano.Effects of exercise qigong on the expression of lipids and lipid-metabolism-related genes in elderly patients with atherosclerosis.2020,Vol.1,21-29.

[1] Zu Deling, Zhuge Yi, Wang Xinhua, etc Study on the correlation between cystatin C, plasma atherogenic index and hypertension [J] Preventive Medicine, 2018, 30 (6): 43-45+50.

[2] Chen Weijun Effects of folic acid adjuvant therapy on lipid metabolism and carotid atherosclerotic plaque properties in hypertensive patients with hyperhomocysteinemia [J] Journal of Guangzhou Medical University, 2017, 45 (5): 55-57

[3] Xia Qinghong A comparative study on the effects of square dance on blood lipid and lipoprotein metabolism of elderly women in Jingdezhen [J] Journal of Jingdezhen University, 2017, 32 (6): 86-89

[4] Chen Jing, Fu Juan, Liu Na, et al Influence of Helicobacter pylori infection on related indexes and carotid atherosclerosis in patients with coronary heart disease [J] Chinese Journal of Hospital Infection, 2016, 26 (13): 2972-2974

[5] Zhang Jie, Ma Xin, Sun Xiaoqing, et al Effects of fitness Qigong Baduanjin on blood lipid and antioxidant level of middle-aged and elderly people [J] Shandong Sports Science and Technology, 2016, 38 (2): 65-68

[6] Liu Tao, Bai Shi, Zhang Rongchao Effect of fitness Qigong Baduanjin on relevant indexes of obese middle-aged women with diabetes [J] Chinese Journal of Applied Physiology, 2018, 34 (1): 19-22

[7] Zhu Xiaofeng, Li Zexin Study on the effect of winter swimming exercise on the elasticity of arteries and blood vessels of middle-aged and elderly women [J] Chongqing Medical Journal, 2017, 46 (3): 322-324

[8] Lee K, Yu Y. Lipid bilayer disruption induced by amphiphilic Janus nanoparticles: the non-monotonic effect of charged lipids[J].  Soft Matter, 2019, 15(11).

[9] Li Yingxue, Zhang Qi, Shang Xiaoming, et al Experimental Study on the Lipid Regulating and Anti atherosclerosis Effects of Shenshao Oral Liquid [J] Chinese Journal of Coal Industry Medicine, 2017, 20 (07): 64-67